Associate Professor Guenova Margarita Lubenova, MD, PhD

National Specialized Hospital for Active Treatment of Haematological Diseases

6, Plovdivsko Pole Street, Sofia 1756
phone: +359 2 9701222, fax: +359 2 9701107

email: margenova@cetrh.org

• Bulgarian Society of Clinical and Transfusion Haematology – Board member,
• Bulgarian Society of Clinical Pathology,
• Bulgarian Association of Clinical Immunology,
• European Haematology Association (EHA) - Membership Committee,
• European Association of Haematopathology (EAHP),
• International Union Against Cancer (UICC),
• Balkan Society of Haematology,
• Journal of Clinical and Transfusion Haematology – editorial board,
• Haema – Jornal of the Hellenic Society of Haematology – editorial board

• Award of the Union of Scientific Medical Societies named Prof. Vasil Molov, 1999г.
• Award of the National Science Fund of the Ministry of Education and Science of the group of scientific project No L411 during 4^th concurs session 1994-1997
• Award of the National Science Fund of the Ministry of Education and Science in 8^th concurs session 1998-2001

Barcelona University, University Hospital Clinic, Department of Pathology, Modern immunological, molecular and cytogenetic approaches in haematopathology - March 2007

1. Guenova M., Flow cytometry in Transfusion medicine. In: Lissitchkov, T., (ed.) Transfusion Haematology [in
   Bulgarian], Sofia, 2003: 747-770
2. In: Lissitchkov, T., Meshkov T. (eds.) Clinical Haematology [in Bulgarian], Sofia, 2004
   • Guenova, M., Flow cytometry in haematology ( differentiation antigens, immunophenotyping, cell cycle,
     apoptosis): 299-328
   • Guenova, M., Chronic idiopatic myelofibrosis. 1133-1139
   • Guenova, M., Т-cell and NK-cell neoplasias. 1319-1369
   • Peichev, D., Guenova, M., Treatment f T-cell and NK-cell neoplasias. 1371-1381
   • Hodjadjik, J., Guenova, M., Rare subtypes of lymphoproliferative diseases. (lymphomas). 1383-1389.
3. Guenova,M., Taskov, H., Zechev, J., CD4+ Acute undifferentiated leukaemia, probably early monoblastic
   type, developing in a patient with myelodysplastic syndrome and bone marrow fibrosis. Leukemia and
   Lymphoma, 26(3-4): 399-404, 1997
4. Nikolova, M., Guenova, M., Taskov, H., Dimitrova, E., Staneva, M., Levels of expression of CAF7 (CD98)
   have prognostic significance in adult acute leukemia. Leukemia Research, 22(1):39-47, 1998
5. Mitev, L., Christova, S., Hadjiev, E., Guenova,M., Oucheva, R., Valkov, I., Manolova, J., A new variant
   chromosomal translocation t(2;2)(p23;q23) in CD30+/Ki-1+ anaplastic large cell lymphoma. Leukemia and
   Lymphoma, 28(5-6): 613-616, 1998
6. Grudeva-Popova,J., Anavi,B., Gugushev,M., Genova, M., A case of Gastric medullary carcinoma with
   lymphoid infitration. Journal of BUON, 4(2):211-213, 1999
7. Guenova,M., Rassidakis, G., Gourgoulis, V., Angeloupoulou,M., Siakantaris, M., Kanavaros, P., Pangalis, G.,
   Kittas, C., p16INK4A is regularly expressed in Hodgkin’s Disease: Comparison with Retinoblastoma, p53,
   MDM2 protein status, and the presence of Epstein-Barr Virus. Modern Pathology, 12(11):1062-1071, 1999
8. Guenova, M., Hodgkin’s Disease: Conventional and Molecular Pathology. Postgraduate Athens Leukaemia -
   Lymphoma Course, Athens, 16th-20th October, 1999: 362-381
9. Guenova, M., P53, mdm2 isoforms & WAF1/cip1 proteins in Hodgkin’s lymphomas. In: Association of UICC
   Fellows (AUF) Membership Directory 1999. http://fellows.uicc.org/directory/ere98icg.html, 1999: 8-10
10. Balatzenko, G. and Guenova, M., Light microscopic detection of BCR-ABL transcripts after in-cell RT-PCR:
    Fusion gene expression might correlate with evolution of chronic myeloid leukemia. Leukemia and Lymphoma,
    36(3-4): 383-396, 2000
11. Guenova, M., Kulaksazov, P., Staneva, M., Meshkov, T., Detection of minimal residual disease in acute
    leukaemia patients by multi-parameter flow cytometry. Comp.rev.de Acad.bulg.Sci, 53(10): 115-118, 2000
12. Konstantinov, S., Kostovski, A., Topashka, M., Guenova, M., Berger, M., Comparative cytotoxic efficacy of
    Bendamustine on human leukemia and breast cancer cell lines. Journal of Cancer Research and Clinical
    Oncology, 128: 271-278, 2002
13. Balatzenko, G., Stoimenov, A., Guenova, M., Galabova, I., Ganeva, P., Hodjadjik, D., Toshkov, S.,
    Application of reverse transcription polymerase chain reaction for analysis of multidrug resistance in patients
    with acute myeloblastic leukemia. J BUON, 7 (4), 2002
14. Guenova, M., Staneva, M., Hodgkin’s Disease: Conventional and Molecular Pathology. Prognostic
    implications. Athens Postgraduate Athens Leukaemia - Lymphoma Course Book, 2002: 421-442
15. Michova, А., Guenova, M., Nikolova, M., Taskov, H., CD13 epitope 7H5 exhibits a particular expression
    pattern in haematological malignancies. Haema, 6(3): 336-343, 2003
16. Balatzenko G, Guenova M, Zechev J, Toshkov S. Acute megakaryoblastic leukaemia with extreme
    thrombocytosis and p190(bcr/abl)rearrangement. Ann Hematol., 83(6):381-5, 2004
17. Staneva M, Zhechev Y, Stoimenov A, Balatzenko G, Guenova M. Clonal heterogeneity in a patient with acute
    promyelocytic leukemia. J BUON ;9(2):197-200, 2004
18. Tsoneva I, Nikolova B, Georgieva M, Guenova M, Tomov T, Rols MP, Berger MR. Induction of apoptosis by
    electrotransfer of positively charged proteins as Cytochrome C and Histone H1 into cells. Biochim Biophys
    Acta., 1721(1-3):55-64, 2005
19. Nikolova M, Guenova M, Taskov H, Marie-Cardine A, Boumsell L, Bensussan A. SC3 monoclonal antibody
    defines a novel specific human B-cell surface antigen differentially expressed on B-cell leukaemias and
    lymphomas and involved in the proliferation of normal and malignant B lymphocytes.
    Cell Immunol.; 236(1-2):92-100, 2005
20. Shivarov V, Dimitrov J, Guenova M. Lymphoid neoplasms in Bulgaria according to the WHO classification
    (2001). The experience of the National Center of Haematology. Haematologica;90(12 Suppl):ELT07, 2005
21. M.Guenova, Mediastinal Lymphomas. Course Book. Diagnostic Tutorial on Lyphoma Pathology, 2006
22. Shivarov V, Nikolova V, Balatzenko G, Guenova M. Microgranular relapse of typical hypergranular acute
    promyelocytic leukemia. Leuk Lymphoma;47(12):2661-3, 2006
23. Guenova M. & G. Balatzenko, An Integrated Approach to Diagnosis and Prognosis of Leukaemias. In
    Proceedings of International Conference on Emerging Trends in Haematology & Immunohaematology,
    Mumbai, 31st January-3rd February 2007: 269-278, 2007
24. Nikolova V., I Amin, G Balatzenko, M Guenova, Study of the intracellular levels of apoptotic and antiapototic
    proteins in Myelodysplastic syndromes and acyte myeloid leukaemias [In Bulgarian], Infectology, 2007 [in
    press]
25. Mihailov G., Ganeva P., Vassileva N., Guenova M., Balacenko G., Toshkov S., Hodjadjik D. Secondary acute
    myeloid leukemia early after therapy for Hodgkin’s lymphoma - case report, Journal of BUON, 12(3): 403-6,
    2007
26. Shivarov V., Stoimenov A., Galabova I., Balatzenko G., Guenova M. Very early onset of an acute myeloid
    leukemia in an adult patient with B-cell lymphoblastic leukemia. Intern J Lab Hematol, (in press) doi:
    2007;10.1111/j.1751-553X.
27. Balatzenko G., Guenova M., Stoimenov A., Jotov G., Toshkov S. Philadelphia Chromosome-Positive Chronic
    Myeloid Leukemia with p190BCR-ABL Rearrangement, Overexpression of EVI1 gene and Extreme
    Thrombocytosis – a Case Report. Cancer Genetics and Cytogenetics, 181(1):75-7, 2008
28. Guenova M. & Balatzenko G., CD133-2 (AC141) Expression Analysis in Acute Leukemia Phenotyping in
    Correlation to CD34 and P-Glycoprotein. Hematology, 2008 [in press]
29. Guenova, M, Balatzenko, G, Nikolova, V., Spassov, B, Konstantinov, S. An Anti-Apoptotic Pattern Correlates
    with Multidrug Resistance in Acute Myeloid Leukemia Patients: A Comparative Study of Active Caspase-3,
    Cleaved PARPs, Bcl-2, Survivin and MDR1 Gene. Ann N Y Acad Sci., 2008 [in press]
    30. Spassov, S, Guenova, M, Balatzenko, G, Momekov, G, Konstantinov, S. Expression of Wilms’ tumor 1 and
    nuclear factor kappa B proteins in blast cells of de novo acute myeloid leukemias. Ann N Y Acad Sci., 2008 [in
    press]
30. Stein, H., R. Von Wasielewski, S. Poppema, K.A. MacLennan, M. Guenova. Chapter 85.Nodular sclerosis
    classical Hodgkin lymphoma. In: E. Campo, N. L. Harris, E. S. Jaffe, S. Pileri et al. (eds). Pathology and
    Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of
    Tumours. Lyon, France: IARC Press; 2008 [in press]