Екип

Координатор на консорциума

Членове на научния колектив

 
д-р Маргарита Генова

д-р Маргарита Любенова Генова,
ст.н.с. ІІ ст., д.м.

Координатор на консорциума

Организация, контакти:

Национална специализирана болница за активно лечение на хематалогични заболявания

ул. "Пловдивско поле" № 6, 1756, гр. София
тел: (02) 9701222, факс: (02) 9701107

email: margenova@cetrh.org

Членства в научни организации:
  • Българско дружество по клинична и трансфузионна хематология - член на Управителния съвет;
  • Българско дружество по клинична патология;
  • Българска асоциация по клинична имунология;
  • European Haematology Association (EHA) - Membership Committee;
  • European Association of Haematopathology (EAHP);
  • International Union Against Cancer (UICC);
  • Balkan Society of Haematology;
  • Списание „Клинична и трансфузионна хематология” - редакционна колегия;
  • Списание “Haema-Journal of the Hellenic Society of Haematology” - редакционна колегия.
Научни награди:
  • Награда на научните медицински дружества на името на проф. Васил Молов, 1999 година.
  • Награда на Национален фонд „Научни изследвания”на МОН на научния колектив на научно-изследователски проект №Л-411 през Четвърта конкурсна сесия 1994-1997 година.
  • Награда на Национален съвет „Научни изследвания” МОН през Осма конкурсна сесия 1998-2001 година.
Специализации и работа в чужбина:

Университет на Барселона, Катедра по патология, Съвременни имунологични, молекулярни и цитогенетични методи в хемотопатологията - март, 2007

Основни публикации
  1. Guenova M., Flow cytometry in Transfusion medicine. In: Lissitchkov, T., (ed.) Transfusion Haematology [in
    Bulgarian], Sofia, 2003: 747-770
  2. In: Lissitchkov, T., Meshkov T. (eds.) Clinical Haematology [in Bulgarian], Sofia, 2004
    • Guenova, M., Flow cytometry in haematology ( differentiation antigens, immunophenotyping, cell cycle,
      apoptosis): 299-328
    • Guenova, M., Chronic idiopatic myelofibrosis. 1133-1139
    • Guenova, M., Т-cell and NK-cell neoplasias. 1319-1369
    • Peichev, D., Guenova, M., Treatment f T-cell and NK-cell neoplasias. 1371-1381
    • Hodjadjik, J., Guenova, M., Rare subtypes of lymphoproliferative diseases. (lymphomas). 1383-1389.
  3. Guenova,M., Taskov, H., Zechev, J., CD4+ Acute undifferentiated leukaemia, probably early monoblastic
    type, developing in a patient with myelodysplastic syndrome and bone marrow fibrosis. Leukemia and
    Lymphoma, 26(3-4): 399-404, 1997
  4. Nikolova, M., Guenova, M., Taskov, H., Dimitrova, E., Staneva, M., Levels of expression of CAF7 (CD98)
    have prognostic significance in adult acute leukemia. Leukemia Research, 22(1):39-47, 1998
  5. Mitev, L., Christova, S., Hadjiev, E., Guenova,M., Oucheva, R., Valkov, I., Manolova, J., A new variant
    chromosomal translocation t(2;2)(p23;q23) in CD30+/Ki-1+ anaplastic large cell lymphoma. Leukemia and
    Lymphoma, 28(5-6): 613-616, 1998
  6. Grudeva-Popova,J., Anavi,B., Gugushev,M., Genova, M., A case of Gastric medullary carcinoma with
    lymphoid infitration. Journal of BUON, 4(2):211-213, 1999
  7. Guenova,M., Rassidakis, G., Gourgoulis, V., Angeloupoulou,M., Siakantaris, M., Kanavaros, P., Pangalis, G.,
    Kittas, C., p16INK4A is regularly expressed in Hodgkin’s Disease: Comparison with Retinoblastoma, p53,
    MDM2 protein status, and the presence of Epstein-Barr Virus. Modern Pathology, 12(11):1062-1071, 1999
  8. Guenova, M., Hodgkin’s Disease: Conventional and Molecular Pathology. Postgraduate Athens Leukaemia -
    Lymphoma Course, Athens, 16th-20th October, 1999: 362-381
  9. Guenova, M., P53, mdm2 isoforms & WAF1/cip1 proteins in Hodgkin’s lymphomas. In: Association of UICC
    Fellows (AUF) Membership Directory 1999. http://fellows.uicc.org/directory/ere98icg.html, 1999: 8-10
  10. Balatzenko, G. and Guenova, M., Light microscopic detection of BCR-ABL transcripts after in-cell RT-PCR:
    Fusion gene expression might correlate with evolution of chronic myeloid leukemia. Leukemia and Lymphoma,
    36(3-4): 383-396, 2000
  11. Guenova, M., Kulaksazov, P., Staneva, M., Meshkov, T., Detection of minimal residual disease in acute
    leukaemia patients by multi-parameter flow cytometry. Comp.rev.de Acad.bulg.Sci, 53(10): 115-118, 2000
  12. Konstantinov, S., Kostovski, A., Topashka, M., Guenova, M., Berger, M., Comparative cytotoxic efficacy of
    Bendamustine on human leukemia and breast cancer cell lines. Journal of Cancer Research and Clinical
    Oncology, 128: 271-278, 2002
  13. Balatzenko, G., Stoimenov, A., Guenova, M., Galabova, I., Ganeva, P., Hodjadjik, D., Toshkov, S.,
    Application of reverse transcription polymerase chain reaction for analysis of multidrug resistance in patients
    with acute myeloblastic leukemia. J BUON, 7 (4), 2002
  14. Guenova, M., Staneva, M., Hodgkin’s Disease: Conventional and Molecular Pathology. Prognostic
    implications. Athens Postgraduate Athens Leukaemia - Lymphoma Course Book, 2002: 421-442
  15. Michova, А., Guenova, M., Nikolova, M., Taskov, H., CD13 epitope 7H5 exhibits a particular expression
    pattern in haematological malignancies. Haema, 6(3): 336-343, 2003
  16. Balatzenko G, Guenova M, Zechev J, Toshkov S. Acute megakaryoblastic leukaemia with extreme
    thrombocytosis and p190(bcr/abl)rearrangement. Ann Hematol., 83(6):381-5, 2004
  17. Staneva M, Zhechev Y, Stoimenov A, Balatzenko G, Guenova M. Clonal heterogeneity in a patient with acute
    promyelocytic leukemia. J BUON ;9(2):197-200, 2004
  18. Tsoneva I, Nikolova B, Georgieva M, Guenova M, Tomov T, Rols MP, Berger MR. Induction of apoptosis by
    electrotransfer of positively charged proteins as Cytochrome C and Histone H1 into cells. Biochim Biophys
    Acta., 1721(1-3):55-64, 2005
  19. Nikolova M, Guenova M, Taskov H, Marie-Cardine A, Boumsell L, Bensussan A. SC3 monoclonal antibody
    defines a novel specific human B-cell surface antigen differentially expressed on B-cell leukaemias and
    lymphomas and involved in the proliferation of normal and malignant B lymphocytes.
    Cell Immunol.; 236(1-2):92-100, 2005
  20. Shivarov V, Dimitrov J, Guenova M. Lymphoid neoplasms in Bulgaria according to the WHO classification
    (2001). The experience of the National Center of Haematology. Haematologica;90(12 Suppl):ELT07, 2005
  21. M.Guenova, Mediastinal Lymphomas. Course Book. Diagnostic Tutorial on Lyphoma Pathology, 2006
  22. Shivarov V, Nikolova V, Balatzenko G, Guenova M. Microgranular relapse of typical hypergranular acute
    promyelocytic leukemia. Leuk Lymphoma;47(12):2661-3, 2006
  23. Guenova M. & G. Balatzenko, An Integrated Approach to Diagnosis and Prognosis of Leukaemias. In
    Proceedings of International Conference on Emerging Trends in Haematology & Immunohaematology,
    Mumbai, 31st January-3rd February 2007: 269-278, 2007
  24. Nikolova V., I Amin, G Balatzenko, M Guenova, Study of the intracellular levels of apoptotic and antiapototic
    proteins in Myelodysplastic syndromes and acyte myeloid leukaemias [In Bulgarian], Infectology, 2007 [in
    press]
  25. Mihailov G., Ganeva P., Vassileva N., Guenova M., Balacenko G., Toshkov S., Hodjadjik D. Secondary acute
    myeloid leukemia early after therapy for Hodgkin’s lymphoma - case report, Journal of BUON, 12(3): 403-6,
    2007
  26. Shivarov V., Stoimenov A., Galabova I., Balatzenko G., Guenova M. Very early onset of an acute myeloid
    leukemia in an adult patient with B-cell lymphoblastic leukemia. Intern J Lab Hematol, (in press) doi:
    2007;10.1111/j.1751-553X.
  27. Balatzenko G., Guenova M., Stoimenov A., Jotov G., Toshkov S. Philadelphia Chromosome-Positive Chronic
    Myeloid Leukemia with p190BCR-ABL Rearrangement, Overexpression of EVI1 gene and Extreme
    Thrombocytosis – a Case Report. Cancer Genetics and Cytogenetics, 181(1):75-7, 2008
  28. Guenova M. & Balatzenko G., CD133-2 (AC141) Expression Analysis in Acute Leukemia Phenotyping in
    Correlation to CD34 and P-Glycoprotein. Hematology, 2008 [in press]
  29. Guenova, M, Balatzenko, G, Nikolova, V., Spassov, B, Konstantinov, S. An Anti-Apoptotic Pattern Correlates
    with Multidrug Resistance in Acute Myeloid Leukemia Patients: A Comparative Study of Active Caspase-3,
    Cleaved PARPs, Bcl-2, Survivin and MDR1 Gene. Ann N Y Acad Sci., 2008 [in press]
    30. Spassov, S, Guenova, M, Balatzenko, G, Momekov, G, Konstantinov, S. Expression of Wilms’ tumor 1 and
    nuclear factor kappa B proteins in blast cells of de novo acute myeloid leukemias. Ann N Y Acad Sci., 2008 [in
    press]
  30. Stein, H., R. Von Wasielewski, S. Poppema, K.A. MacLennan, M. Guenova. Chapter 85.Nodular sclerosis
    classical Hodgkin lymphoma. In: E. Campo, N. L. Harris, E. S. Jaffe, S. Pileri et al. (eds). Pathology and
    Genetics of Tumours of Haematopoietic and Lymphoid Tissues. World Health Organization Classification of
    Tumours. Lyon, France: IARC Press; 2008 [in press]